RNA-built droplets create customizable organelles inside living cells

Just as the human body relies on organs such as the heart or liver for essential functions, cells depend on their own tiny ...

Captured mid-reaction, RNA polymerase reveals universal blueprint for gene transcription

The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and ...
Technology Networks

Transcriptomics Reveals Adipocyte Beiging as a Metabolic Disease Drug Target

Transcriptomic phenotyping offers mechanistic insight into adipocyte biology and metabolic disease. A signature of adipocyte ...

Cancer cells can rewrite RNA messages, creating new drug targets in aggressive tumors

Scientists have uncovered an unexpected way cells can generate cancer-driving proteins—by cutting RNA into shorter, ...
eLife

The structure of Egalitarian in complex with the K10 mRNA localization signal reveals a modular binding surface required for function

This manuscript has convincing data that provides a high-resolution structure of the Egl-RNA complex. The findings are important to understand the formation, stability, and interactions of this ...