Now, however, a surprising discovery about BH4 will likely rekindle interest in the once-promising pathway and could have profound implications for treating autoimmunity and cancer. In today's Nature, ...

Researchers have identified a molecule sent by fat cells to the fly brain that senses when they have had enough food and inhibits feeding. Researchers have identified a molecule sent by fat cells to ...

A team of scientists in Vienna, including an Irish researcher, has made a substantial breakthrough that could help us fight cancer in a new way. The foundational work by the winners of this year’s ...

A surprising discovery about a failed pain drug -- and specifically, the pathway it targets, BH4 -- could have implications for autoimmunity and cancer. Neuroscientists report that BH4 also functions ...

'Reverse engineering' the BH4 pathway reveals sepiapterin reductase as a new target for analgesic treatments. This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human ...